Jaffè Method - Fixed time

Bireagent

Quantitative determination of Creatinine on serum and urine.

Creatinine is the result of phosphocreatine catabolism and its production is strictly related to the organism’s muscular mass. It is entirely eliminated in urine through renal ultra-filtration. If the filtration function of kidneys is regular, creatinine concentration in serum and the quantity eliminated through urine are constant.

In case of renal deterioration, the kidney cannot eliminate the right amount of creatinine in the blood: this leads to an increase in the substance, which doubles at each 50% reduction of kidney filtration capacity.